The bone tissue is procured, tested and processed according to the EU Directivesand Austrian Tissue Law. The essential characteristic of processing is that SUPERCRITICAL CO2 TECHNOLOGY(scCO2) is used, currently the most gentle and effective, validated technology of cleaning bone allografts.
Supercritical CO2 has the ability of high penetration throughout the whole bone matrix combined with high potential to solve lipids and cellular components associated with lipids.
Using this technology lipids and bone marrow are removed, while the collagen matrix consisting of collagen and minerals is mainly maintained. OSTEOINDUCTIVE proteins are treated with care. The native composition of the matrix promotes OSTEOCONDUCTION.
The virus-inactivating effect of the process has been validated several times. By removing fat and cellular components antigens are removed and immunological reactions are avoided.
The purified matrix is impregnated with high loads of antibiotics. Due to the proprietary impregnation technique the antibiotic is deposited throughout the whole graft, mainly in the lacunae of the spongy matrix.
OSmycin™ elutes antibiotics slowly. Thus higher local antibiotic concentration and longer lasting antimicrobial activity is achieved better than with any other method.
Release of the antibiotic is completed after several weeks and such is not likely to create resistances or initiate the formation of small colony variants.
Concentrations in the immediate surrounding reach levels between 100 and 1000 times the levels reachable with systemic antibiotic therapy.
Because of the unique properties of supercritical CO2 this innovative processing technology enables efficient and gentle cleaning of human bone allografts – also for cortical and massive allografts – and guarantees ultimate biological safety and quality of the products.
Due to the special impregnation technique antibiotics are eluted slowly. Higher local antibiotic concentration and longer lasting antimicrobial activity is achieved better than with any other method.